Most men begin injection therapy with Trimix, which is a mixture of 3 ingredients: alprostadil, phentolamine, and papaverine. The 3 most commonly used medications for injection therapy are Trimix, Bimix, and papaverine. If you’re using tadalafil (Cialis) 5 mg daily, ask your APP how you should use this medication along with your injections. If you take tadalafil (Cialis ®) 10 mg or 20 mg, do not inject within 72 hours (3 days) of taking the medication. Use this resource to help you the first few times you inject on your own. Please be aware that each visit may take up to 1 hour, so you should plan your schedule on the day of your appointment. Generally, the training for the injections takes 2 office visits. Your advanced practice provider (APP) will review the instructions below with you. Back to top Giving Yourself the Injection It works best if it’s given about 5 to 15 minutes before you want an erection. A penile injection helps you have an erection. We believe having erections keeps erectile tissue healthy. Going long periods of time without an erection is unhealthy for erectile tissue and may damage it. The tissue that causes you to get an erection (erectile tissue) is a muscle. ![]() Back to top About Penile Injection Therapy ![]() If you do not follow the instructions in this resource, your doctor or APP may stop prescribing your penile injection medications and supplies. ![]() Read this resource carefully before starting injection therapy. Penile injections can help you achieve an erection if you have erectile dysfunction (ED). This information will help you learn to inject medication into your penis.
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